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Washington, March 9 (ANI): Yale School of Medicine researchers say they have found a new method of growing arteries that could lead to a ‘biological bypass’—or a non-invasive way to treat coronary artery disease.

Coronary arteries can become blocked with plaque, leading to a decrease in the supply of blood and oxygen to the heart. Over time this blockage can lead to debilitating chest pain or heart attack. Severe blockages in multiple major vessels may require coronary artery bypass graft surgery, a major invasive surgery.

“Successfully growing new arteries could provide a biological option for patients facing bypass surgery,” said lead author of the study Michael Simons, chief of the Section of Cardiology at Yale School of Medicine.

In the past, researchers used growth factors—proteins that stimulate the growth of cells—to grow new arteries, but this method was unsuccessful.

Simons and his team studied mice and zebrafish to see if they could simulate arterial formation by switching on and off two signaling pathways—ERK1/2 and P13K.

“We found that there is a cross-talk between the two signaling pathways. One half of the signaling pathway inhibits the other. When we inhibit this mechanism, we are able to grow arteries. Instead of using growth factors, we stopped the inhibitor mechanism by using a drug that targets a particular enzyme called P13-kinase inhibitor,” said Simons.

“Because we”ve located this inhibitory pathway, it opens the possibility of developing a new class of medication to grow new arteries. The next step is to test this finding in a human clinical trial,” Simons added.

The new research has been described in the April issue of Journal of Clinical Investigation.(ANI)

London, Mar 9 (ANI): Researchers at University of Michigan have identified a new reservoir for hidden HIV-infected cells that can serve as a factory for new infections.

The findings indicate a new target for curing the disease so that those infected with the virus might not have to rely on AIDS drugs for a lifetime.
“Antiviral drugs [...]

London, Mar 9 (ANI): Opera singer Placido Domingo has undergone surgery for colon cancer, revealed a spokesman.

The crooner had a cancerous polyp removed last week at Mount Sinai Hospital in New York and he was released on Monday, said Nancy Seltzer.
She added that the cancerous growth was small and that Domingo was expected to make [...]

Sydney, Mar 8 (ANI): An Australian study has revealed that humans have a sixth taste by which they can detect fat.

Using a series of taste-testing experiments, researchers from Deakin University have found that humans can identify the taste of fat by its chemical composition, rather than by its texture.
They say it appears that those people [...]

London, Mar 8 (ANI): The AIDS virus, HIV, can dodge treatment by staying dormant inside progenitor blood cells that develop into immune cells.

These cellular reservoirs are resistant to the immune response of the host and the highly active antiretroviral therapy (HAART) administered to patients.
This means that the virus can attack white blood cells known as [...]

Washington, March 8 (ANI): Men employed in occupations with potential exposure to high levels of sunlight have a reduced risk of kidney cancer compared with men who are less likely to be exposed to sunlight at work, according to a new study.

Research suggests that vitamin D, which is obtained from sun exposure, some foods, and [...]

London, March 8 (ANI): Having two cups of black tea or one cup of green tea a day can help cut down risk of developing ovarian cancer in women, says a study.

Researchers at the University of Washington studied 2,000 women and noticed a 54 per cent risk reduction in those who drank one or more [...]

London, March 8 (ANI): Vitamin D plays an important role in activating our immune defenses against infectious diseases like flu, says a new study.

According to the research, without sufficient intake of the vitamin, the killer cells of the immune system – T cells – will not be able to react to and fight off serious [...]

Melbourne, Mar 7 (ANI): A man diagnosed with a rare, incurable lymphoma claims that he has been able to cheat death for 13 years by eating apricot kernels.

Paul Reid insists that the ””cancer-killing”” properties in the kernels, rich in vitamin B17, and a strict vegetarian diet have cured him, despite the doctors telling him he [...]

London, Mar 7 (ANI): Female wine drinkers can take heart: A new study has shown that moderate drinkers have a lower risk of obesity than teetotalers.

The study, which included more than 19,000 women, also found that ladies who enjoy a glass of wine after work are likely to gain less weight than those who stick [...]